Effect of Diclofenac with B Vitamins on the Treatment of Acute Pain Originated by Lower-Limb Fracture and Surgery

Abstract EN

The aim of this study was to compare the efficacy of diclofenac, for the treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins.

This was a single-center, prospective, randomized, and double-blinded clinical trial.

Patients with lower-limb closed fractures rated their pain on a 10 cm visual analog scale (VAS).

Patients were then randomized to receive diclofenac or diclofenac plus B vitamins (thiamine, pyridoxine, and cyanocobalamin) intramuscularly twice daily.

Patient evaluations of pain intensity were recorded throughout two periods: twenty-four hours presurgery and twenty-four hours postsurgical.

One hundred twenty-two patients completed the study.

The subjects' assessments of limb pain on the VAS showed a significant reduction from baseline values regardless of the treatment group.

Diclofenac plus B vitamins combination was more effective to reduce the pain than diclofenac alone.

The results showed that the addition of B vitamins to diclofenac increased its analgesic effect.

The novelty of this paper consists in that diclofenac and diclofenac plus B vitamins were useful for treatment of acute pain originated by lower-limb fracture and surgery.