Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves
Joint Authors
Campbell, William
Etusim, Paschal
Melariri, Paula
Smith, Peter
Source
Journal of Parasitology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We investigated the antiplasmodial properties of crude extracts from Carica papaya leaves to trace the activity through bioassay-guided fractionation.
The greatest antiplasmodial activity was observed in the ethyl acetate crude extract.
C.
papaya showed a high selectivity for P.
falciparum against CHO cells with a selectivity index of 249.25 and 185.37 in the chloroquine-sensitive D10 and chloroquine-resistant DD2 strains, respectively.
Carica papaya ethyl acetate extract was subjected to bioassay-guided fractionation to ascertain the most active fraction, which was purified and identified using high-pressure liquid chromatography (HPLC) and GC-MS (Gas chromatography-Mass spectrometry) methods.
Linoleic and linolenic acids identified from the ethyl acetate fraction showed IC50 of 6.88 μg/ml and 3.58 μg/ml, respectively.
The study demonstrated greater antiplasmodial activity of the crude ethyl acetate extract of Carica papaya leaves with an IC50 of 2.96±0.14 μg/ml when compared to the activity of the fractions and isolated compounds.
American Psychological Association (APA)
Melariri, Paula& Campbell, William& Etusim, Paschal& Smith, Peter. 2011. Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-446729
Modern Language Association (MLA)
Melariri, Paula…[et al.]. Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves. Journal of Parasitology Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-446729
American Medical Association (AMA)
Melariri, Paula& Campbell, William& Etusim, Paschal& Smith, Peter. Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-446729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446729
