Early-Life Origins of Type 2 Diabetes : Fetal Programming of the Beta-Cell Mass
Joint Authors
Portha, Bernard
Movassat, Jamileh
Chavey, Audrey
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
A substantial body of evidence suggests that an abnormal intrauterine milieu elicited by maternal metabolic disturbances as diverse as undernutrition, placental insufficiency, diabetes or obesity, may program susceptibility in the fetus to later develop chronic degenerative diseases, such as obesity, hypertension, cardiovascular diseases and diabetes.
This paper examines the developmental programming of glucose intolerance/diabetes by disturbed intrauterine metabolic condition experimentally obtained in various rodent models of maternal protein restriction, caloric restriction, overnutrition or diabetes, with a focus on the alteration of the developing beta-cell mass.
In most of the cases, whatever the type of initial maternal metabolic stress, the beta-cell adaptive growth which normally occurs during gestation, does not take place in the pregnant offspring and this results in the development of gestational diabetes.
Therefore gestational diabetes turns to be the ultimate insult targeting the offspring beta-cell mass and propagates diabetes risk to the next generation again.
The aetiology and the transmission of spontaneous diabetes as encountered in the GK/Par rat model of type 2 diabetes, are discussed in such a perspective.
This review also discusses the non-genomic mechanisms involved in the installation of the programmed effect as well as in its intergenerational transmission.
American Psychological Association (APA)
Portha, Bernard& Chavey, Audrey& Movassat, Jamileh. 2011. Early-Life Origins of Type 2 Diabetes : Fetal Programming of the Beta-Cell Mass. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-446737
Modern Language Association (MLA)
Portha, Bernard…[et al.]. Early-Life Origins of Type 2 Diabetes : Fetal Programming of the Beta-Cell Mass. Experimental Diabetes Research No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-446737
American Medical Association (AMA)
Portha, Bernard& Chavey, Audrey& Movassat, Jamileh. Early-Life Origins of Type 2 Diabetes : Fetal Programming of the Beta-Cell Mass. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-446737
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446737