The Novelty of Human CancerTestis Antigen Encoding Genes in Evolution
Joint Authors
Dobrynin, Pavel
Kozlov, Andrei P.
Matyunina, Ekaterina
Malov, S. V.
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In order to be inherited in progeny generations, novel genes should originate in germ cells.
Here, we suggest that the testes may play a special “catalyst” role in the birth and evolution of new genes.
Cancer/testis antigen encoding genes (CT genes) are predominantly expressed both in testes and in a variety of tumors.
By the criteria of evolutionary novelty, the CT genes are, indeed, novel genes.
We performed homology searches for sequences similar to human CT in various animals and established that most of the CT genes are either found in humans only or are relatively recent in their origin.
A majority of all human CT genes originated during or after the origin of Eutheria.
These results suggest relatively recent origin of human CT genes and align with the hypothesis of the special role of the testes in the evolution of the gene families.
American Psychological Association (APA)
Dobrynin, Pavel& Matyunina, Ekaterina& Malov, S. V.& Kozlov, Andrei P.. 2013. The Novelty of Human CancerTestis Antigen Encoding Genes in Evolution. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-446740
Modern Language Association (MLA)
Dobrynin, Pavel…[et al.]. The Novelty of Human CancerTestis Antigen Encoding Genes in Evolution. International Journal of Genomics No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-446740
American Medical Association (AMA)
Dobrynin, Pavel& Matyunina, Ekaterina& Malov, S. V.& Kozlov, Andrei P.. The Novelty of Human CancerTestis Antigen Encoding Genes in Evolution. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-446740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446740