![](/images/graphics-bg.png)
Proteomics Shows New Faces for the Old Penicillin Producer Penicillium chrysogenum
Joint Authors
Martín, Juan F.
Barreiro, Carlos
García-Estrada, Carlos
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Fungi comprise a vast group of microorganisms including the Ascomycota (majority of all described fungi), the Basidiomycota (mushrooms or higher fungi), and the Zygomycota and Chytridiomycota (basal or lower fungi) that produce industrially interesting secondary metabolites, such as β-lactam antibiotics.
These compounds are one of the most commonly prescribed drugs world-wide.
Since Fleming's initial discovery of Penicillium notatum 80 years ago, the role of Penicillium as an antimicrobial source became patent.
After the isolation of Penicillium chrysogenum NRRL 1951 six decades ago, classical mutagenesis and screening programs led to the development of industrial strains with increased productivity (at least three orders of magnitude).
The new “omics” era has provided the key to understand the underlying mechanisms of the industrial strain improvement process.
The review of different proteomics methods applied to P.
chrysogenum has revealed that industrial modification of this microorganism was a consequence of a careful rebalancing of several metabolic pathways.
In addition, the secretome analysis of P.
chrysogenum has opened the door to new industrial applications for this versatile filamentous fungus.
American Psychological Association (APA)
Barreiro, Carlos& Martín, Juan F.& García-Estrada, Carlos. 2012. Proteomics Shows New Faces for the Old Penicillin Producer Penicillium chrysogenum. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-446741
Modern Language Association (MLA)
Barreiro, Carlos…[et al.]. Proteomics Shows New Faces for the Old Penicillin Producer Penicillium chrysogenum. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-446741
American Medical Association (AMA)
Barreiro, Carlos& Martín, Juan F.& García-Estrada, Carlos. Proteomics Shows New Faces for the Old Penicillin Producer Penicillium chrysogenum. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-446741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446741