Carvedilol Ameliorates Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats
Joint Authors
Hassan, Magdy K.
Abdelwahab, Soha A.
Kamel, Maha Y.
Morsy, Mohamed A.
Ibrahim, Salwa A.
Amin, Entesar F.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetic nephropathy results in end-stage renal disease.
On the other hand, carvedilol has been reported to have various pharmacological properties.
The aim of this study therefore is to evaluate the possible protective effect of carvedilol on streptozotocin-induced early diabetic nephropathy and various mechanisms underlie this effect in rats.
Single i.p.
injection of streptozotocin (65 mg/kg) was administered to induce early diabetic nephropathy in Wistar rats.
Oral administration of carvedilol at a dose level of 1 and 10 mg/kg daily for 4 weeks resulted in nephroprotective effect as evident by significant decrease in serum creatinine level, urinary albumin/creatinine ratio, and kidney index as well as renal levels of malondialdehyde, nitric oxide, tumor necrosis factor-α, and cyclooxygenase-2 with a concurrent increase in creatinine clearance and renal reduced glutathione level compared to diabetic untreated rats.
The protective effect of carvedilol was confirmed by renal histopathological examination.
The electron microscopic examination indicated that carvedilol could effectively ameliorate glomerular basement membrane thickening and podocyte injury.
In conclusion, carvedilol protects rats against streptozotocin-induced early diabetic nephropathy possibly, in part, through its antioxidant as well as anti-inflammatory activities, and ameliorating podocyte injury.
American Psychological Association (APA)
Morsy, Mohamed A.& Ibrahim, Salwa A.& Amin, Entesar F.& Kamel, Maha Y.& Abdelwahab, Soha A.& Hassan, Magdy K.. 2014. Carvedilol Ameliorates Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-446748
Modern Language Association (MLA)
Morsy, Mohamed A.…[et al.]. Carvedilol Ameliorates Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-446748
American Medical Association (AMA)
Morsy, Mohamed A.& Ibrahim, Salwa A.& Amin, Entesar F.& Kamel, Maha Y.& Abdelwahab, Soha A.& Hassan, Magdy K.. Carvedilol Ameliorates Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-446748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446748