Foetal Haemoglobin, Erythrocytes Containing Foetal Haemoglobin, and Hematological Features in Congolese Patients with Sickle Cell Anaemia
Joint Authors
Kinsiama, C.
Avvisati, G.
Tshilolo, L.
Gregorj, C.
Labie, D.
Bazeboso, J. A.
Summa, V.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
High HbF levels and F cells are correlated with reduced morbidity and mortality in sickle cell disease (SCD).
This paper was designed to determine the HbF and F cells levels in Congolese sickle cell anemia (SCA) patients in order to determine their impact on the expression of SCD.
Population and Method.
HbF levels were measured in 89 SCA patients (mean age 11.4 yrs) using a standard HPLC method.
F cell quantitation was done in a second group of SCA patients (n=42, mean age 8.9 yrs) and compared with a control group (n=47, mean age 5 yrs).
F cells were quantified by a cytofluorometric system (MoAb-HbF—FITC; cut off at 0.5%).
Results.
The mean value of HbF was 7.2% ± 5.0 with heterogeneous distribution, most patients (76%) having HbF < 8%.
Mean values of F-cells in SCA patients and control group were 5.4% ± 7.6 (median: 2.19% ; range 0,0–30,3%) and 0.5% ± 1.6 (median 0.0, range 0–5.18), respectively.
SCA patients with F cells >4.5% developed less painful crisis and had higher percentage of reticulocytes.
Conclusion.
Congolese SCA patients displayed low levels of HbF and F-cells that contribute to the severity of SCD.
American Psychological Association (APA)
Tshilolo, L.& Summa, V.& Gregorj, C.& Kinsiama, C.& Bazeboso, J. A.& Avvisati, G.…[et al.]. 2012. Foetal Haemoglobin, Erythrocytes Containing Foetal Haemoglobin, and Hematological Features in Congolese Patients with Sickle Cell Anaemia. Anemia،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446764
Modern Language Association (MLA)
Tshilolo, L.…[et al.]. Foetal Haemoglobin, Erythrocytes Containing Foetal Haemoglobin, and Hematological Features in Congolese Patients with Sickle Cell Anaemia. Anemia No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-446764
American Medical Association (AMA)
Tshilolo, L.& Summa, V.& Gregorj, C.& Kinsiama, C.& Bazeboso, J. A.& Avvisati, G.…[et al.]. Foetal Haemoglobin, Erythrocytes Containing Foetal Haemoglobin, and Hematological Features in Congolese Patients with Sickle Cell Anaemia. Anemia. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-446764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446764