![](/images/graphics-bg.png)
Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This review focuses on recent developments in the molecular mechanisms by which Ca activates cardiac sarcomeres and how these mechanisms play out in the cardiac cycle.
I emphasize the role of mechanisms intrinsic to the sarcomeres as significant determinants of systolic elastance and ventricular stiffening during ejection.
Data are presented supporting the idea that processes intrinsic to the thin filaments may promote cooperative activation of the sarcomeres and be an important factor in maintaining and modifying systolic elastance.
Application of these ideas to translational medicine and rationale drug design forms an important rationale for detailed understanding of these processes.
American Psychological Association (APA)
Solaro, R. John. 2010. Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-446785
Modern Language Association (MLA)
Solaro, R. John. Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-446785
American Medical Association (AMA)
Solaro, R. John. Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-446785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446785