The Role of the Actin Cytoskeleton and Lipid Rafts in the Localization and Function of the ABCC1 Transporter
Joint Authors
Hummel, Ina
Klappe, Karin
Kok, Jan Willem
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
ATP-binding cassette (ABC) transporters are known to be important factors in multidrug resistance of tumor cells.
Lipid rafts have been implicated in their localization in the plasma membrane, where they function as drug efflux pumps.
This specific localization in rafts may support the activity of ABC/Abc transporters.
This raises questions regarding the nature and composition of the lipid rafts that harbor ABC/Abc transporters and the dependence of ABC/Abc transporters—concerning their localization and activity—on lipid raft constituents.
Here we review our work of the past 10 years aimed at evaluating whether ABC/Abc transporters are dependent on a particular membrane environment for their function.
What is the nature of this membrane environment and which of the lipid raft constituents are important for this dependency? It turns out that cortical actin is of major importance for stabilizing the localization and function of the ABC/Abc transporter, provided it is localized in an actin-dependent subtype of lipid rafts, as is the case for human ABCC1/multidrug resistance-related protein 1 (MRP1) and rodent Abcc1/Mrp1 but not human ABCB1/P-glycoprotein (PGP).
On the other hand, sphingolipids do not appear to be modulators of ABCC1/MRP1 (or Abcc1/Mrp1), even though they are coregulated during drug resistance development.
American Psychological Association (APA)
Kok, Jan Willem& Klappe, Karin& Hummel, Ina. 2014. The Role of the Actin Cytoskeleton and Lipid Rafts in the Localization and Function of the ABCC1 Transporter. Advances in Biology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-446808
Modern Language Association (MLA)
Kok, Jan Willem…[et al.]. The Role of the Actin Cytoskeleton and Lipid Rafts in the Localization and Function of the ABCC1 Transporter. Advances in Biology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-446808
American Medical Association (AMA)
Kok, Jan Willem& Klappe, Karin& Hummel, Ina. The Role of the Actin Cytoskeleton and Lipid Rafts in the Localization and Function of the ABCC1 Transporter. Advances in Biology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-446808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446808