Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults
Joint Authors
Boffito, Marta
Amara, Alieu
Kiweewa, Francis
Tamale, William S.
Byakika-Kibwika, Pauline
Tjia, John
Khoo, Saye
Kityo, Cissy
Ryan, Mairin
Back, David
Lamorde, Mohammed
Merry, Concepta
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We investigated the effect of food on the steady-state pharmacokinetics of a proprietary fixed-dose combination (FDC) tablet containing tenofovir disoproxil fumarate (TDF)/emtricitabine/efavirenz.
Fifteen Ugandan HIV-1 patients at steady-state dosing with TDF/emtricitabine/efavirenz were admitted for 24-hour intensive pharmacokinetic sampling after dosing in the fasting state.
Blood sampling was repeated seven days later with TDF/emtricitabine/efavirenz administered with food (19 g fat).
Drug concentrations in plasma were determined by liquid chromatography and tandem mass spectrometry.
Geometric mean ratios (GMRs) and confidence intervals (CIs) of parameters were calculated (reference, fasting).
For efavirenz, GMRs (90% CIs) for Cmax, AUC0-24, and C24 were 1.47 (1.24–1.75), 1.13 (1.03–1.23), and 1.01 (0.91–1.11), respectively.
Corresponding GMRs were 1.04 (0.84–1.27), 1.19 (1.10–1.29), and 0.99 (0.82–1.19) for tenofovir, 0.83 (0.76–0.92), 0.87 (0.78–0.97), and 0.91 (0.73–1.14) for emtricitabine.
Stable patients may take the FDC without meal restrictions.
The FDC should be taken without food by patients experiencing central nervous system toxicities.
American Psychological Association (APA)
Lamorde, Mohammed& Byakika-Kibwika, Pauline& Tamale, William S.& Kiweewa, Francis& Ryan, Mairin& Amara, Alieu…[et al.]. 2012. Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-446819
Modern Language Association (MLA)
Lamorde, Mohammed…[et al.]. Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults. AIDS Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-446819
American Medical Association (AMA)
Lamorde, Mohammed& Byakika-Kibwika, Pauline& Tamale, William S.& Kiweewa, Francis& Ryan, Mairin& Amara, Alieu…[et al.]. Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-446819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446819