A Randomised, Double-Blind Pilot Study of Enzyme-Potentiated Desensitisation for Prophylaxis of Large Local Reactions to Mosquito Bites
Joint Authors
Ambler, G.
Berkovitz, S.
Hill, N.
Radcliffe, M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Primary Objective.
To test the hypothesis that two injections of enzyme-potentiated mosquito antigen significantly reduce the size of experimental mosquito bites in participants with LLR-MB.
Design.
Randomised, double-blind, placebo-controlled, parallel group comparison over 3 months.
Setting.
Hospital outpatient clinic.
Participants.
Fifty adult participants of both sexes.
Interventions.
Two injections of mosquito antigen or matching placebo, 6 weeks apart.
Main Outcome Measures.
Early (1 hour) and late (24 hours) mean square root of erythema area (SREA) following controlled mosquito bite with the second bite given at least 6 weeks following the final injection.
Results.
At 1 hour, mean SREA was slightly higher in the EPD group compared to placebo after adjusting for baseline values (0.46, 95% CI −6.11 to 7.03), but this was not statistically significant (P=0.89, ANCOVA analysis); neither were the results at 24 hours (−2.58, 95% CI −11.73 to 6.57) (P=0.57).
The proportion of participants experiencing a decrease in wheal size at 1 or 24 hours was similar between groups.
Conclusions.
EPD was not demonstrated to be effective for immediate or delayed LLR-MB.
Methodological problems included a high variability in LLR-MB between subjects, suggesting that a crossover design should be used in future.
American Psychological Association (APA)
Berkovitz, S.& Hill, N.& Radcliffe, M.& Ambler, G.. 2012. A Randomised, Double-Blind Pilot Study of Enzyme-Potentiated Desensitisation for Prophylaxis of Large Local Reactions to Mosquito Bites. Journal of Allergy،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-446828
Modern Language Association (MLA)
Berkovitz, S.…[et al.]. A Randomised, Double-Blind Pilot Study of Enzyme-Potentiated Desensitisation for Prophylaxis of Large Local Reactions to Mosquito Bites. Journal of Allergy No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-446828
American Medical Association (AMA)
Berkovitz, S.& Hill, N.& Radcliffe, M.& Ambler, G.. A Randomised, Double-Blind Pilot Study of Enzyme-Potentiated Desensitisation for Prophylaxis of Large Local Reactions to Mosquito Bites. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-446828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446828