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The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia
Joint Authors
Yildirim, Nesligul
Sayin, Muhammet Rasit
Dogan, Sait Mesut
Aktop, Ziyaettin
Arasli, Mehmet
Tekin, Ishak Ozel
Aydin, Mustafa
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background/Aim.
Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis.
Tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation.
The aim of this study was to evaluate the plasma levels of the cytokines; TNF-α and IL-6 in CAE patients.
Methods.
Plasma concentrations of TNF-α and IL-6 were measured in 36 patients with CAE (28 males, mean age: 58.2±12 years), and results were compared with age and sex-matched controls (n=32) without coronary artery ectasia.
TNF-α and IL-6 concentrations in blood were assesed by enzyme-linked immunosorbent assay (ELISA).
Results.
Baseline characteristics of the two groups were similar.
TNF-α and IL-6 levels were significantly higher in CAE group than controls (15.6±11.2 pg/mL versus 7.8±3.7 pg/mL, P<.001, and 17.2±12.6 versus 7.6±2.1 , P<.0001, resp.).
Conclusion.
CAE patients showed increases in TNF-α and IL-6 levels compared to the controls.
This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of CAE.
Further placebo-controlled studies are needed to evaluate the clinical significance of this increase in TNF-α and IL-6 levels.
American Psychological Association (APA)
Aydin, Mustafa& Tekin, Ishak Ozel& Dogan, Sait Mesut& Yildirim, Nesligul& Arasli, Mehmet& Sayin, Muhammet Rasit…[et al.]. 2009. The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-446834
Modern Language Association (MLA)
Aydin, Mustafa…[et al.]. The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia. Mediators of Inflammation No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-446834
American Medical Association (AMA)
Aydin, Mustafa& Tekin, Ishak Ozel& Dogan, Sait Mesut& Yildirim, Nesligul& Arasli, Mehmet& Sayin, Muhammet Rasit…[et al.]. The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-446834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446834