Mixed-Ligand Nickel(II)‎ Complexes Containing Sulfathiazole and Cephalosporin Antibiotics : Synthesis, Characterization, and Antibacterial Activity

Abstract EN

Nickel(II) reacts with cephalosporins plus sulfathiazole (Hstz) to form the following mixed-ligand complexes of general formulae [Ni(L)(stz)(H2O)x]n (L1,4, x=1; L2,3, x=0; L = monoanion of cefazolin HL1, cephalothin HL2, cefotaxime HL3, ceftriaxone HL4) and [Ni(L5)(stz)]Cl (cefepime L5), which were characterized by physicochemical and spectroscopic methods.

Their spectra indicated that cephalosporins are acting as multidentate chelating agents, via the lactam carbonyl and carboxylate and N-azomoieties.

The complexes are insoluble in water and common organic solvents but soluble in DMSO, where the [Ni(L5)(stz)]Cl complex is 1 : 1 electrolyte.

They probably have polymeric structures.

They have been screened for antibacterial activity, and the results are compared with the activity of commercial cephalosporins.