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Immune Modulating Capability of Two Exopolysaccharide-Producing Bifidobacterium Strains in a Wistar Rat Model
Joint Authors
López, Patricia
Garrido, Pablo
Moran, Javier
Ruas-Madiedo, Patricia
de los Reyes-Gavilán, Clara G.
Gueimonde, Miguel
Salazar, Nuria
Suárez, Ana
González, Celestino
Cabello, Estefanía
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fermented dairy products are the usual carriers for the delivery of probiotics to humans, Bifidobacterium and Lactobacillus being the most frequently used bacteria.
In this work, the strains Bifidobacterium animalis subsp.
lactis IPLA R1 and Bifidobacterium longum IPLA E44 were tested for their capability to modulate immune response and the insulin-dependent glucose homeostasis using male Wistar rats fed with a standard diet.
Three intervention groups were fed daily for 24 days with 10% skimmed milk, or with 109 cfu of the corresponding strain suspended in the same vehicle.
A significant increase of the suppressor-regulatory TGF-β cytokine occurred with both strains in comparison with a control (no intervention) group of rats; the highest levels were reached in rats fed IPLA R1.
This strain presented an immune protective profile, as it was able to reduce the production of the proinflammatory IL-6.
Moreover, phosphorylated Akt kinase decreased in gastroctemius muscle of rats fed the strain IPLA R1, without affecting the glucose, insulin, and HOMA index in blood, or levels of Glut-4 located in the membrane of muscle and adipose tissue cells.
Therefore, the strain B.
animalis subsp.
lactis IPLA R1 is a probiotic candidate to be tested in mild grade inflammation animal models.
American Psychological Association (APA)
Salazar, Nuria& López, Patricia& Garrido, Pablo& Moran, Javier& Cabello, Estefanía& Gueimonde, Miguel…[et al.]. 2014. Immune Modulating Capability of Two Exopolysaccharide-Producing Bifidobacterium Strains in a Wistar Rat Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-446855
Modern Language Association (MLA)
Salazar, Nuria…[et al.]. Immune Modulating Capability of Two Exopolysaccharide-Producing Bifidobacterium Strains in a Wistar Rat Model. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-446855
American Medical Association (AMA)
Salazar, Nuria& López, Patricia& Garrido, Pablo& Moran, Javier& Cabello, Estefanía& Gueimonde, Miguel…[et al.]. Immune Modulating Capability of Two Exopolysaccharide-Producing Bifidobacterium Strains in a Wistar Rat Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-446855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446855