Effect of Trandolapril on Regression of Retinopathy in Hypertensive Patients with Type 2 Diabetes : A Prespecified Analysis of the Benedict Trial
Joint Authors
Ganeva, Maria
Iliev, Ilian
Filipponi, Marco
Tadini, Stefano
Perna, Annalisa
Remuzzi, Giuseppe
Ruggenenti, Piero
Trevisan, Roberto
Cravedi, Paolo
Ene-Iordache, Bogdan
Bossi, Antonio
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The effect of angiotensin converting enzyme inhibitors (ACEi) on regression of retinopathy in type 2 diabetics is still ill defined.
Methods.
We compared the incidence of retinopathy regression in 90 hypertensive type 2 diabetics randomized to at least 3-year blinded ACEi with trandolapril (2 mg/day) or non-ACEi therapy who had preproliferative or proliferative retinopathy at baseline.
Results.
Over a median (interquartile range) follow-up period of 35.8 (12.4–60.7) months, retinopathy regressed in 27 patients (30.0%).
Regression occurred in 18 of 42 patients (42.9%) on ACEi and in 9 of 48 (18.8%) on non-ACEi therapy (adjusted for predefined baseline covariates HR (95% CI): 2.75 (1.18–6.42), P=.0193).
Concomitant treatment with or without Non-Dihydropyridine Calcium Channel Blockers (ndCCBs) did not appreciably affect the incidence of retinopathy regression.
Conclusions.
Unlike ndCCB, ACEi therapy may have an additional effect to that of intensified BP and metabolic control in promoting regression of diabetic retinopathy.
American Psychological Association (APA)
Ruggenenti, Piero& Iliev, Ilian& Filipponi, Marco& Tadini, Stefano& Perna, Annalisa& Ganeva, Maria…[et al.]. 2010. Effect of Trandolapril on Regression of Retinopathy in Hypertensive Patients with Type 2 Diabetes : A Prespecified Analysis of the Benedict Trial. Journal of Ophthalmology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-446867
Modern Language Association (MLA)
Ruggenenti, Piero…[et al.]. Effect of Trandolapril on Regression of Retinopathy in Hypertensive Patients with Type 2 Diabetes : A Prespecified Analysis of the Benedict Trial. Journal of Ophthalmology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-446867
American Medical Association (AMA)
Ruggenenti, Piero& Iliev, Ilian& Filipponi, Marco& Tadini, Stefano& Perna, Annalisa& Ganeva, Maria…[et al.]. Effect of Trandolapril on Regression of Retinopathy in Hypertensive Patients with Type 2 Diabetes : A Prespecified Analysis of the Benedict Trial. Journal of Ophthalmology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-446867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446867