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Apocynin : Molecular Aptitudes
Joint Authors
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Apocynin is a naturally occurring methoxy-substituted catechol, experimentally used as an inhibitor of NADPH-oxidase.
It can decrease the production of superoxide (O2−) from activated neutrophils and macrophages while the ability of phagocytosis remains unaffected.
The anti-inflammatory activity of apocynin has been demonstrated in a variety of cell and animal models of inflammation.
Apocynin, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production.
It is, therefore, extensively used to reveal the role of this enzyme in cell and experimental models.
Although some of the ROS serve as signaling molecules in the cells, excessive production is damaging and has been implicated to play an important role in the progression of many disease processes.
This is why in many studies apocynin presents a promising potential treatment for some disorders; however, its utility with inflammatory diseases remains to be determined.
Since its mode of action is not well defined, we tried to get a more precise insight into the mechanisms by which apocynin exerts its activity.
Considering the anti-inflammatory activities of apocynin, we may conclude that this compound definitely deserves further study.
American Psychological Association (APA)
Stefanska, J.& Pawliczak, R.. 2008. Apocynin : Molecular Aptitudes. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-446884
Modern Language Association (MLA)
Stefanska, J.& Pawliczak, R.. Apocynin : Molecular Aptitudes. Mediators of Inflammation No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-446884
American Medical Association (AMA)
Stefanska, J.& Pawliczak, R.. Apocynin : Molecular Aptitudes. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-446884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446884