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Molecular Regulation of Striatal Development : A Review
Joint Authors
Evans, A. E.
Rosser, A. E.
Precious, S. V.
Kelly, C. M.
Source
Anatomy Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The central nervous system is composed of the brain and the spinal cord.
The brain is a complex organ that processes and coordinates activities of the body in bilaterian, higher-order animals.
The development of the brain mirrors its complex function as it requires intricate genetic signalling at specific times, and deviations from this can lead to brain malformations such as anencephaly.
Research into how the CNS is specified and patterned has been studied extensively in chick, fish, frog, and mice, but findings from the latter will be emphasised here as higher-order mammals show most similarity to the human brain.
Specifically, we will focus on the embryonic development of an important forebrain structure, the striatum (also known as the dorsal striatum or neostriatum).
Over the past decade, research on striatal development in mice has led to an influx of new information about the genes involved, but the precise orchestration between the genes, signalling molecules, and transcription factors remains unanswered.
We aim to summarise what is known to date about the tightly controlled network of interacting genes that control striatal development.
This paper will discuss early telencephalon patterning and dorsal ventral patterning with specific reference to the genes involved in striatal development.
American Psychological Association (APA)
Evans, A. E.& Kelly, C. M.& Precious, S. V.& Rosser, A. E.. 2012. Molecular Regulation of Striatal Development : A Review. Anatomy Research International،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-446886
Modern Language Association (MLA)
Evans, A. E.…[et al.]. Molecular Regulation of Striatal Development : A Review. Anatomy Research International No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-446886
American Medical Association (AMA)
Evans, A. E.& Kelly, C. M.& Precious, S. V.& Rosser, A. E.. Molecular Regulation of Striatal Development : A Review. Anatomy Research International. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-446886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446886