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Animal Models of Diabetic Retinopathy : Summary and Comparison
Joint Authors
Lo, Amy Cheuk Yin
Lai, Angela Ka Wai
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-29, 29 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
29
Main Subjects
Abstract EN
Diabetic retinopathy (DR) is a microvascular complication associated with chronic exposure to hyperglycemia and is a major cause of blindness worldwide.
Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced.
In order to have a better understanding of the development of DR at the molecular and cellular levels, a variety of animal models have been developed.
They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms).
In this review, we summarize the existing protocols to induce diabetes using STZ.
We also describe and compare the pathological presentations, in both morphological and functional aspects, of the currently available DR animal models.
The advantages and disadvantages of using different animals, ranging from zebrafish, rodents to other higher-order mammals, are also discussed.
Until now, there is no single model that displays all the clinical features of DR as seen in human.
Yet, with the understanding of the pathological findings in these animal models, researchers can select the most suitable models for mechanistic studies or drug screening.
American Psychological Association (APA)
Lai, Angela Ka Wai& Lo, Amy Cheuk Yin. 2013. Animal Models of Diabetic Retinopathy : Summary and Comparison. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-29.
https://search.emarefa.net/detail/BIM-446891
Modern Language Association (MLA)
Lai, Angela Ka Wai& Lo, Amy Cheuk Yin. Animal Models of Diabetic Retinopathy : Summary and Comparison. Journal of Diabetes Research No. 2013 (2013), pp.1-29.
https://search.emarefa.net/detail/BIM-446891
American Medical Association (AMA)
Lai, Angela Ka Wai& Lo, Amy Cheuk Yin. Animal Models of Diabetic Retinopathy : Summary and Comparison. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-29.
https://search.emarefa.net/detail/BIM-446891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446891