PARP1-Driven Apoptosis in Chronic Lymphocytic Leukemia
Joint Authors
Papadopoulou, Vasiliki
Polonyfi, Katerina
Iliakis, Theodoros
Viniou, Nora-Athina
Sofotasiou, Maria
Diamantopoulos, Panagiotis T.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chronic lymphocytic leukemia (CLL) is considered a malignancy resulting from defects in apoptosis.
For this reason, targeting apoptotic pathways in CLL may be valuable for its management.
Poly [ADP-ribose] polymerase 1 (PARP1) is the main member of a family of nuclear enzymes that act as DNA damage sensors.
Through binding on DNA damaged structures, PARP1 recruits repair enzymes and serves as a survival factor, but if the damage is severe enough, its action may lead the cell to apoptosis through caspase activation, or necrosis.
We measured the PARP1 mRNA and protein pretreatment levels in 26 patients with CLL and the corresponding posttreatment levels in 15 patients after 3 cycles of immunochemotherapy, as well as in 15 healthy blood donors.
No difference was found between the pre- and posttreatment levels of PARP1, but we found a statistically significant relative increase of the 89 kDa fragment of PARP1 that is cleaved by caspases in the posttreatment samples, indicating PARP1-related apoptosis in CLL patients after treatment.
Our findings constitute an important step in the field, especially in the era of PARP1 inhibitors, and may serve as a base for future clinical trials with these agents in CLL.
American Psychological Association (APA)
Diamantopoulos, Panagiotis T.& Sofotasiou, Maria& Papadopoulou, Vasiliki& Polonyfi, Katerina& Iliakis, Theodoros& Viniou, Nora-Athina. 2014. PARP1-Driven Apoptosis in Chronic Lymphocytic Leukemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-446892
Modern Language Association (MLA)
Diamantopoulos, Panagiotis T.…[et al.]. PARP1-Driven Apoptosis in Chronic Lymphocytic Leukemia. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-446892
American Medical Association (AMA)
Diamantopoulos, Panagiotis T.& Sofotasiou, Maria& Papadopoulou, Vasiliki& Polonyfi, Katerina& Iliakis, Theodoros& Viniou, Nora-Athina. PARP1-Driven Apoptosis in Chronic Lymphocytic Leukemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-446892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446892