Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon
Joint Authors
Wolfe, Alan J.
Reimann, Sylvia A.
Source
International Journal of Microbiology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Bacteria adapt to changing environments by means of tightly coordinated regulatory circuits.
The use of synthetic lethality, a genetic phenomenon in which the combination of two nonlethal mutations causes cell death, facilitates identification and study of such circuitry.
In this study, we show that the E.
coli ompR malTcon double mutant exhibits a synthetic lethal phenotype that is environmentally conditional.
MalTcon, the constitutively active form of the maltose system regulator MalT, causes elevated expression of the outer membrane porin LamB, which leads to death in the absence of the osmoregulator OmpR.
However, the presence and metabolism of glycolytic carbon sources, such as sorbitol, promotes viability and unveils a novel layer of regulation within the complex circuitry that controls maltose transport and metabolism.
American Psychological Association (APA)
Reimann, Sylvia A.& Wolfe, Alan J.. 2011. Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon. International Journal of Microbiology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-446916
Modern Language Association (MLA)
Reimann, Sylvia A.& Wolfe, Alan J.. Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon. International Journal of Microbiology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-446916
American Medical Association (AMA)
Reimann, Sylvia A.& Wolfe, Alan J.. Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon. International Journal of Microbiology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-446916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446916