Insights into the Structures of DNA Damaged by Hydroxyl Radical : Crystal Structures of DNA Duplexes Containing 5-Formyluracil
Joint Authors
Matsuda, Akira
Abe, Naoko
Naito, Satoko
Tsunoda, Masaru
Sunami, Tomoko
Ueno, Yoshihito
Sakaue, Takeshi
Takénaka, Akio
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives.
One of the major damaged thymine derivatives is 5-formyluracil (fU), which induces pyrimidine transition during replication.
In order to establish the structural basis for such mutagenesis, the crystal structures of two kinds of DNA d(CGCGRATfUCGCG) with R = A/G have been determined by X-ray crystallography.
The fU residues form a Watson-Crick-type pair with A and two types of pairs (wobble and reversed wobble) with G, the latter being a new type of base pair between ionized thymine base and guanine base.
In silico structural modeling suggests that the DNA polymerase can accept the reversed wobble pair with G, as well as the Watson-Crick pair with A.
American Psychological Association (APA)
Tsunoda, Masaru& Sakaue, Takeshi& Naito, Satoko& Sunami, Tomoko& Abe, Naoko& Ueno, Yoshihito…[et al.]. 2010. Insights into the Structures of DNA Damaged by Hydroxyl Radical : Crystal Structures of DNA Duplexes Containing 5-Formyluracil. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-446955
Modern Language Association (MLA)
Tsunoda, Masaru…[et al.]. Insights into the Structures of DNA Damaged by Hydroxyl Radical : Crystal Structures of DNA Duplexes Containing 5-Formyluracil. Journal of Nucleic Acids No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-446955
American Medical Association (AMA)
Tsunoda, Masaru& Sakaue, Takeshi& Naito, Satoko& Sunami, Tomoko& Abe, Naoko& Ueno, Yoshihito…[et al.]. Insights into the Structures of DNA Damaged by Hydroxyl Radical : Crystal Structures of DNA Duplexes Containing 5-Formyluracil. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-446955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446955