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Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives
Joint Authors
Liu, Xinyong
Song, Yu'ning
Zhang, Qingzhu
Kang, Dongwei
Zhan, Peng
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A new series of 9-(1-(substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine derivatives were designed, synthesized, and characterized on the basis of 1H-NMR, 13C-NMR, and mass spectra.
The newly synthesized compounds were evaluated for the inhibition activity against acetylcholinesterase (AChE).
Biological results revealed that four compounds among them showed moderate activities against AChE with inhibitory percentage more than 10% at 100 μM.
Further pharmacology investigation towards other pathological routes in AD is currently underway.
American Psychological Association (APA)
Kang, Dongwei& Song, Yu'ning& Zhan, Peng& Zhang, Qingzhu& Liu, Xinyong. 2013. Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-446959
Modern Language Association (MLA)
Kang, Dongwei…[et al.]. Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives. Journal of Chemistry No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-446959
American Medical Association (AMA)
Kang, Dongwei& Song, Yu'ning& Zhan, Peng& Zhang, Qingzhu& Liu, Xinyong. Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-446959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446959