Enhanced Antidepressant-Like Effects of Electroacupuncture Combined with Citalopram in a Rat Model of Depression
Joint Authors
Gong, Xiao-Li
Pei, Yu
Wang, Xiao-Min
Wang, Xuan
Yu, Yan
Pan, Yan-Li
Jia, Jun
Li, Bo
Deng, Jia-Hui
Shi, Chen
Ma, Xin
Yang, Jian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Currently, antidepressants are the dominative treatment for depression, but they have limitations in efficacy and may even produce troublesome side effects.
Electroacupuncture (EA) has been reported to have therapeutic benefits in the treatment of depressive disorders.
The present study was conducted to determine whether EA could enhance the antidepressant efficacy of a low dose of citalopram (an SSRI antidepressant) in the chronic unpredictable stress-induced depression model rats.
Here, we show that a combined treatment with 2 Hz EA and 5 mg/kg citalopram for three weeks induces a significant improvement in depressive-like symptoms as detected by sucrose preference test, open field test, and forced swimming test, whereas these effects were not observed with either of the treatments alone.
Further investigations revealed that 2 Hz EA plus 5 mg/kg citalopram produced a remarkably increased expression of BDNF and its receptor TrkB in the hippocampus compared with those measured in the vehicle group.
Our findings suggest that EA combined with a low dose of citalopram could produce greater therapeutic effects, thereby, predictive of a reduction in drug side effects.
American Psychological Association (APA)
Yang, Jian& Pei, Yu& Pan, Yan-Li& Jia, Jun& Shi, Chen& Yu, Yan…[et al.]. 2013. Enhanced Antidepressant-Like Effects of Electroacupuncture Combined with Citalopram in a Rat Model of Depression. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-446970
Modern Language Association (MLA)
Yang, Jian…[et al.]. Enhanced Antidepressant-Like Effects of Electroacupuncture Combined with Citalopram in a Rat Model of Depression. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-446970
American Medical Association (AMA)
Yang, Jian& Pei, Yu& Pan, Yan-Li& Jia, Jun& Shi, Chen& Yu, Yan…[et al.]. Enhanced Antidepressant-Like Effects of Electroacupuncture Combined with Citalopram in a Rat Model of Depression. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-446970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446970