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Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome
Joint Authors
Tomada, Inês
Tomada, Nuno
Pacheco-Figueiredo, Luís
Carvalho, Hugo Nogueira
Costa, Inês Campos
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Erectile dysfunction (ED), metabolic syndrome (MetS), and hypogonadism are closely related, often coexisting in the aging male.
Obesity was shown to raise the risk of ED and hypogonadism, as well as other endocrinological disturbances with impact on erectile function.
We selected 179 patients referred for ED to our andrology unit, aiming to evaluate gonadotropins and estradiol interplay in context of ED, MetS, and hypogonadism.
Patients were stratified into groups in accordance with the presence (or not) of MetS and/or hypogonadism.
Noticeable differences in total testosterone (TT) and free testosterone (FT) levels were found between patients with and without MetS.
Men with MetS evidenced lower TT circulating levels with an increasing number of MetS parameters, for which hypertriglyceridemia and waist circumference strongly contributed.
Regarding the hypothalamic-pituitary-gonadal axis, patients with hypogonadism did not exhibit raised LH levels.
Interestingly, among those with higher LH levels, estradiol values were also increased.
Possible explanations for this unexpected profile of estradiol may be the age-related adiposity, other estrogen-raising pathways, or even unknown mechanisms.
Estradiol is possibly a molecule with further interactions beyond the currently described.
Our results further enlighten this still unclear multidisciplinary and complex subject, raising new investigational opportunities.
American Psychological Association (APA)
Costa, Inês Campos& Carvalho, Hugo Nogueira& Pacheco-Figueiredo, Luís& Tomada, Inês& Tomada, Nuno. 2013. Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447004
Modern Language Association (MLA)
Costa, Inês Campos…[et al.]. Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-447004
American Medical Association (AMA)
Costa, Inês Campos& Carvalho, Hugo Nogueira& Pacheco-Figueiredo, Luís& Tomada, Inês& Tomada, Nuno. Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447004