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Panic Disorder : Is the PAG Involved?
Joint Authors
Graeff, Frederico Guilherme
Del-Ben, Cristina Marta
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Data from studies with humans have suggested that abnormalities of midbrain structures, including the periaqueductal gray matter (PAG), could be involved in the neurobiology of panic disorder (PD).
The electrical stimulation of the PAG in neurosurgical patients induces panic-like symptoms and the effect of drugs that are effective in the treatment of PD in the simulation of public speaking model of anxiety is in agreement with data from animal models of PD.
Structural neuroimaging studies have shown increases in gray matter volume of midbrain and pons of PD patients.
There is also evidence of lower serotonin transporter and receptor binding, and increases of metabolism in the midbrain of PD patients.
Nevertheless, these midbrain abnormalities can not be considered as specific findings, since neuroimaging data indicate that PD patients have abnormalities in other brain structures that process fear and anxiety.
American Psychological Association (APA)
Del-Ben, Cristina Marta& Graeff, Frederico Guilherme. 2009. Panic Disorder : Is the PAG Involved?. Neural Plasticity،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-447042
Modern Language Association (MLA)
Del-Ben, Cristina Marta& Graeff, Frederico Guilherme. Panic Disorder : Is the PAG Involved?. Neural Plasticity No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-447042
American Medical Association (AMA)
Del-Ben, Cristina Marta& Graeff, Frederico Guilherme. Panic Disorder : Is the PAG Involved?. Neural Plasticity. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-447042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447042