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Microemulsion Drug Delivery System : For Bioavailability Enhancement of Ampelopsin
Joint Authors
Sarkar, Brajesh
Solanki, Shailendra Singh
Dhanwani, Rakesh Kumar
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Ampelopsin, one of the most common flavonoids, reported to possess numerous pharmacological activities and shows poor aqueous solubility.
The purpose of this study was to enhance the dissolution rate and bioavailability of this drug by developing a novel delivery system that is microemulsion (ME) and to study the effect of microemulsion (ME) on the oral bioavailability of ampelopsin.
Capmul MCM-based ME formulation with Cremophor EL as surfactant and Transcutol as cosurfactant was developed for oral delivery of ampelopsin.
Optimised ME was evaluated for its transparency, viscosity, percentage assay and so forth.
Solubilisation capacity of the ME system was also determined.
The prepared ME was compared with the pure drug solution and commercially available tablet for in vitro drug release.
The optimised ME formulation containing ampelopsin, Capmul MCM (5.5%), Cremophor EL (25%), Transcutol P (8.5%), and distilled water showed higher in vitro drug release, as compared to plain drug suspension and the suspension of commercially available tablet.
These results demonstrate the potential use of ME for improving the bioavailability of poor water soluble compounds, such as ampelopsin.
American Psychological Association (APA)
Solanki, Shailendra Singh& Sarkar, Brajesh& Dhanwani, Rakesh Kumar. 2012. Microemulsion Drug Delivery System : For Bioavailability Enhancement of Ampelopsin. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-447046
Modern Language Association (MLA)
Solanki, Shailendra Singh…[et al.]. Microemulsion Drug Delivery System : For Bioavailability Enhancement of Ampelopsin. ISRN Pharmaceutics No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-447046
American Medical Association (AMA)
Solanki, Shailendra Singh& Sarkar, Brajesh& Dhanwani, Rakesh Kumar. Microemulsion Drug Delivery System : For Bioavailability Enhancement of Ampelopsin. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-447046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447046