Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease
Joint Authors
Stranahan, Alexis M.
Mattson, Mark P.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
All neurons are not created equal.
Certain cell populations in specific brain regions are more susceptible to age-related changes that initiate regional and system-level dysfunction.
In this respect, neurons in layer II of the entorhinal cortex are selectively vulnerable in aging and Alzheimer's disease (AD).
This paper will cover several hypotheses that attempt to account for age-related alterations among this cell population.
We consider whether specific developmental, anatomical, or biochemical features of neurons in layer II of the entorhinal cortex contribute to their particular sensitivity to aging and AD.
The entorhinal cortex is a functionally heterogeneous environment, and we will also review data suggesting that, within the entorhinal cortex, there is subregional specificity for molecular alterations that may initiate cognitive decline.
Taken together, the existing data point to a regional cascade in which entorhinal cortical alterations directly contribute to downstream changes in its primary afferent region, the hippocampus.
American Psychological Association (APA)
Stranahan, Alexis M.& Mattson, Mark P.. 2010. Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease. Neural Plasticity،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-447048
Modern Language Association (MLA)
Stranahan, Alexis M.& Mattson, Mark P.. Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease. Neural Plasticity No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-447048
American Medical Association (AMA)
Stranahan, Alexis M.& Mattson, Mark P.. Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease. Neural Plasticity. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-447048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447048