Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum : A Druggable Target?
Joint Authors
Coronado, Monika A.
Lindner, Jasmin
Meissner, Kamila Anna
Schettert, Isolmar
Wrenger, Carsten
Zimbres, Flávia M.
Kronenberger, Thales
Sauer, Frank M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Malaria is a deadly infectious disease which affects millions of people each year in tropical regions.
There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable.
It is well established that vitamin biosynthetic pathways, such as the vitamin B6 de novo synthesis present in Plasmodium, are excellent drug targets.
The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism).
American Psychological Association (APA)
Kronenberger, Thales& Lindner, Jasmin& Meissner, Kamila Anna& Zimbres, Flávia M.& Coronado, Monika A.& Sauer, Frank M.…[et al.]. 2014. Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum : A Druggable Target?. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-447074
Modern Language Association (MLA)
Kronenberger, Thales…[et al.]. Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum : A Druggable Target?. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-447074
American Medical Association (AMA)
Kronenberger, Thales& Lindner, Jasmin& Meissner, Kamila Anna& Zimbres, Flávia M.& Coronado, Monika A.& Sauer, Frank M.…[et al.]. Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum : A Druggable Target?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-447074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447074