Induction of Apoptosis by Luteolin Involving Akt Inactivation in Human 786-O Renal Cell Carcinoma Cells
Joint Authors
Wang, Chung-Chiang
Hung, Yu-Yeh
Li, Jian-Ri
Raung, Shue-Ling
Kuan, Yu-Hsiang
Ou, Yen-Chuan
Chen, Chun-Jung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
There is a growing interest in the health-promoting effects of natural substances obtained from plants.
Although luteolin has been identified as a potential therapeutic and preventive agent for cancer because of its potent cancer cell-killing activity, the molecular mechanisms have not been well elucidated.
This study provides evidence of an alternative target for luteolin and sheds light on the mechanism of its physiological benefits.
Treatment of 786-O renal cell carcinoma (RCC) cells (as well as A498 and ACHN) with luteolin caused cell apoptosis and death.
This cytotoxicity was caused by the downregulation of Akt and resultant upregulation of apoptosis signal-regulating kinase-1 (Ask1), p38, and c-Jun N-terminal kinase (JNK) activities, probably via protein phosphatase 2A (PP2A) activation.
In addition to being a concurrent substrate of caspases and event of cell death, heat shock protein-90 (HSP90) cleavage might also play a role in driving further cellular alterations and cell death, at least in part, involving an Akt-related mechanism.
Due to the high expression of HSP90 and Akt-related molecules in RCC and other cancer cells, our findings suggest that PP2A activation might work in concert with HSP90 cleavage to inactivate Akt and lead to a vicious caspase-dependent apoptotic cycle in luteolin-treated 786-O cells.
American Psychological Association (APA)
Ou, Yen-Chuan& Kuan, Yu-Hsiang& Li, Jian-Ri& Raung, Shue-Ling& Wang, Chung-Chiang& Hung, Yu-Yeh…[et al.]. 2013. Induction of Apoptosis by Luteolin Involving Akt Inactivation in Human 786-O Renal Cell Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-447123
Modern Language Association (MLA)
Ou, Yen-Chuan…[et al.]. Induction of Apoptosis by Luteolin Involving Akt Inactivation in Human 786-O Renal Cell Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-447123
American Medical Association (AMA)
Ou, Yen-Chuan& Kuan, Yu-Hsiang& Li, Jian-Ri& Raung, Shue-Ling& Wang, Chung-Chiang& Hung, Yu-Yeh…[et al.]. Induction of Apoptosis by Luteolin Involving Akt Inactivation in Human 786-O Renal Cell Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-447123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447123