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Ethanol Extract of the Flower Chrysanthemum morifolium Augments Pentobarbital-Induced Sleep Behaviors : Involvement of Cl− Channel Activation
Joint Authors
Kim, Jae-Wook
Han, Jin-Yi
Hong, Jin Tae
Eun, Jae Soon
Li, Rihua
Oh, Ki-Wan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Dried Chrysanthemum morifolium flowers have traditionally been used in Korea for the treatment of insomnia.
This study was performed to investigate whether the ethanol extract of Chrysanthemum morifolium flowers (EFC) enhances pentobarbital-induced sleep behaviors.
EFC prolonged sleep time induced by pentobarbital similar to muscimol, a GABAA receptors agonist.
EFC also increased sleep rate and sleep time when administrated with pentobarbital at a subhypnotic dosage.
Both EFC and pentobarbital increased chloride (Cl−) influx in primary cultured cerebellar granule cells.
EFC increased glutamic acid decarboxylase (GAD) expression levels, but had no effect on the expression of α1-, β2-, and γ2-subunits of the GABAA receptor in the hippocampus of a mouse brain.
This is in contrast to treatment with pentobarbital, which showed decreased α1-subunit expression and no change in GAD expression.
In conclusion, EFC augments pentobarbital-induced sleep behaviors; these effects may result from Cl− channel activation.
American Psychological Association (APA)
Kim, Jae-Wook& Han, Jin-Yi& Hong, Jin Tae& Li, Rihua& Eun, Jae Soon& Oh, Ki-Wan. 2011. Ethanol Extract of the Flower Chrysanthemum morifolium Augments Pentobarbital-Induced Sleep Behaviors : Involvement of Cl− Channel Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-447127
Modern Language Association (MLA)
Kim, Jae-Wook…[et al.]. Ethanol Extract of the Flower Chrysanthemum morifolium Augments Pentobarbital-Induced Sleep Behaviors : Involvement of Cl− Channel Activation. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-447127
American Medical Association (AMA)
Kim, Jae-Wook& Han, Jin-Yi& Hong, Jin Tae& Li, Rihua& Eun, Jae Soon& Oh, Ki-Wan. Ethanol Extract of the Flower Chrysanthemum morifolium Augments Pentobarbital-Induced Sleep Behaviors : Involvement of Cl− Channel Activation. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-447127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447127