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Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer
Joint Authors
Sakharkar, Meena K.
Sharma, Karun
Shashni, Babita
Sakharkar, Kishore R.
Dhillon, Sarinder K.
Ranjekar, Prabhakar R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
PPARs are ligand activated transcription factors.
PPARγ agonists have been reported as a new and potentially efficacious treatment of inflammation, diabetes, obesity, cancer, AD, and schizophrenia.
Since cancer cells show dysregulation of glycolysis they are potentially manageable through changes in metabolic environment.
Interestingly, several of the genes involved in maintaining the metabolic environment and the central energy generation pathway are regulated or predicted to be regulated by PPARγ.
The use of synthetic PPARγ ligands as drugs and their recent withdrawal/restricted usage highlight the lack of understanding of the molecular basis of these drugs, their off-target effects, and their network.
These data further underscores the complexity of nuclear receptor signalling mechanisms.
This paper will discuss the function and role of PPARγ in energy metabolism and cancer biology in general and its emergence as a promising therapeutic target in breast cancer.
American Psychological Association (APA)
Sakharkar, Meena K.& Shashni, Babita& Sharma, Karun& Dhillon, Sarinder K.& Ranjekar, Prabhakar R.& Sakharkar, Kishore R.. 2013. Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer. PPAR Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-447140
Modern Language Association (MLA)
Sakharkar, Meena K.…[et al.]. Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer. PPAR Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-447140
American Medical Association (AMA)
Sakharkar, Meena K.& Shashni, Babita& Sharma, Karun& Dhillon, Sarinder K.& Ranjekar, Prabhakar R.& Sakharkar, Kishore R.. Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-447140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447140