FEV1FEV6 : A Reliable, Easy-to-Use, and Cheaper Alternative to FEV1FVC in Diagnosing Airway Obstruction in Indian Population
Joint Authors
Singh, Anupam Kumar
Lohia, Amit
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
FEV1/FEV6 has been proposed as a cheap, reproducible and valid alternative to FEV1/FVC in spirometry.
No Indian data exists on its utility to diagnose airway obstruction.
Aim.
we sought to determine a fixed cut off of FEV1/FEV6 to diagnose obstruction corresponding to FEV1/FVC < 0.70 proposed by GOLD guidelines.
Method.
Spirometry was done on patient referred to a tertiary centre in India.
Age, sex, height weight were recorded in addition to spirometric variables like FEV1, FVC, FEV6.
The sensitivity, specificity, positive and negative predictive values of FEV1/FEV6 were determined with respect to gold standard of FEV1/FVC < 0.70.
Results.
467 spirometries were analysed after meeting the ATS acceptability criteria.
Considering FEV1/FVC < 0.7 as being the gold standard for obstruction, ROC curve was used to determine the best corresponding cut-off for FEV1/FEV6.
The area under the curve was 99.3% (95% CI: 98.1–99.8%), and the FEV1/FEV6 cut-off, corresponding to the greatest sum of sensitivity and specificity, was 73%.
For the total population, the FEV1/FEV6 sensitivity, specificity, PPV, NPV were was 95.7 %, 94.2 %, 87.5 % and 97.9 % respectively.
Agreement by Kappa value between two cut offs was excellent 0.89 (0.87–0.91).
Conclusion.
FEV1/FEV6 < 73% is a new reliable spirometry index to diagnose airway obstruction in Indian population.
American Psychological Association (APA)
Singh, Anupam Kumar& Lohia, Amit. 2012. FEV1FEV6 : A Reliable, Easy-to-Use, and Cheaper Alternative to FEV1FVC in Diagnosing Airway Obstruction in Indian Population. ISRN Pulmonology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-447141
Modern Language Association (MLA)
Singh, Anupam Kumar& Lohia, Amit. FEV1FEV6 : A Reliable, Easy-to-Use, and Cheaper Alternative to FEV1FVC in Diagnosing Airway Obstruction in Indian Population. ISRN Pulmonology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-447141
American Medical Association (AMA)
Singh, Anupam Kumar& Lohia, Amit. FEV1FEV6 : A Reliable, Easy-to-Use, and Cheaper Alternative to FEV1FVC in Diagnosing Airway Obstruction in Indian Population. ISRN Pulmonology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-447141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447141