Perfusion Imaging with SPECT in the Era of Pathophysiology-Based Biomarkers for Alzheimer's Disease
Joint Authors
Kornhuber, Johannes
Degirmenci, Ümüt
Lewczuk, Piotr
Schmidt, Daniela
Kreil, Sebastian
Weih, Markus
Kuwert, Torsten
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
SPECT allows registration of regional cerebral blood flow (rCBF) which is altered in a characteristic temporoparietal pattern in Alzheimer's Dementia.
Numerous studies have shown the diagnostic value of reduced cerebral blood flow and metabolic changes using perfusion SPECT and FDG-PEPT in AD diagnosis as well as in differential diagnosis against frontotemporal dementia, dementia with Lewy bodies and vascular disease.
Recently more pathophysiology-based biomarkers in CSF and Amyloid-PET tracers have been developed that probably have a higher diagnostic accuracy than the more indirect rCBF changes seen in perfusion SPECT.
In the paper review, we describe recent advances in AD biomarkers as well as improvements in the SPECT technique.
American Psychological Association (APA)
Weih, Markus& Degirmenci, Ümüt& Kreil, Sebastian& Lewczuk, Piotr& Schmidt, Daniela& Kornhuber, Johannes…[et al.]. 2010. Perfusion Imaging with SPECT in the Era of Pathophysiology-Based Biomarkers for Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-447172
Modern Language Association (MLA)
Weih, Markus…[et al.]. Perfusion Imaging with SPECT in the Era of Pathophysiology-Based Biomarkers for Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-447172
American Medical Association (AMA)
Weih, Markus& Degirmenci, Ümüt& Kreil, Sebastian& Lewczuk, Piotr& Schmidt, Daniela& Kornhuber, Johannes…[et al.]. Perfusion Imaging with SPECT in the Era of Pathophysiology-Based Biomarkers for Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-447172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447172