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In Vivo and In Vitro Study of a Polylactide-Fiber-Reinforced β-Tricalcium Phosphate Composite Cage in an Ovine Anterior Cervical Intercorporal Fusion Model
Joint Authors
Mannerström, Bettina
Kotilainen, Esa
Huhtala, Heini
Suuronen, Riitta
Leino, Kari
Heino, Harri
Sándor, George K.
Haimi, Suvi
Röyttä, Matias
Aro, Hannu T.
Kuokkanen, Hannu
Pälli, Aliisa
Parkkola, Riitta
Frantzén, Janek
Miettinen, Susanna
Source
International Journal of Biomaterials
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A poly-70L/30DL-lactide (PLA70)–β-tricalcium phosphate (β-TCP) composite implant reinforced by continuous PLA-96L/4D-lactide (PLA96) fibers was designed for in vivo spinal fusion.
The pilot study was performed with four sheep, using titanium cage implants as controls.
The composite implants failed to direct bone growth as desired, whereas the bone contact and the proper integration were evident with controls 6 months after implantation.
Therefore, the PLA70/β-TCP composite matrix material was further analyzed in the in vitro experiment by human and ovine adipose stem cells (hASCs and oASCs).
The composites proved to be biocompatible as confirmed by live/dead assay.
The proliferation rate of oASCs was higher than that of hASCs at all times during the 28 d culture period.
Furthermore, the composites had only a minor osteogenic effect on oASCs, whereas the hASC osteogenesis on PLA70/β-TCP composites was evident.
In conclusion, the composite implant material can be applied with hASCs for tissue engineering but not be evaluated in vivo with sheep.
American Psychological Association (APA)
Frantzén, Janek& Pälli, Aliisa& Kotilainen, Esa& Heino, Harri& Mannerström, Bettina& Huhtala, Heini…[et al.]. 2011. In Vivo and In Vitro Study of a Polylactide-Fiber-Reinforced β-Tricalcium Phosphate Composite Cage in an Ovine Anterior Cervical Intercorporal Fusion Model. International Journal of Biomaterials،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-447176
Modern Language Association (MLA)
Frantzén, Janek…[et al.]. In Vivo and In Vitro Study of a Polylactide-Fiber-Reinforced β-Tricalcium Phosphate Composite Cage in an Ovine Anterior Cervical Intercorporal Fusion Model. International Journal of Biomaterials No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-447176
American Medical Association (AMA)
Frantzén, Janek& Pälli, Aliisa& Kotilainen, Esa& Heino, Harri& Mannerström, Bettina& Huhtala, Heini…[et al.]. In Vivo and In Vitro Study of a Polylactide-Fiber-Reinforced β-Tricalcium Phosphate Composite Cage in an Ovine Anterior Cervical Intercorporal Fusion Model. International Journal of Biomaterials. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-447176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447176