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Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway
Joint Authors
Satoh, Ryosuke
Kita, Ayako
Sugiura, Reiko
Ishiwata, Shunji
Umeda, Nanae
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mitogen-activated protein kinases (MAPKs), which are found in all eukaryotes, are signal transducing enzymes playing a central role in diverse biological processes, such as cell proliferation, sexual differentiation, and apoptosis.
The MAPK signaling pathway plays a key role in the regulation of gene expression through the phosphorylation of transcription factors.
Recent studies have identified several RNA-binding proteins (RBPs) as regulators of MAPK signaling because these RBPs bind to the mRNAs encoding the components of the MAPK pathway and regulate the stability of their transcripts.
Moreover, RBPs also serve as targets of MAPKs because MAPK phosphorylate and regulate the ability of RBPs to bind and stabilize target mRNAs, thus controlling various cellular functions.
In this review, we present evidence for the significance of the MAPK signaling in the regulation of RBPs and their target mRNAs, which provides additional information about the regulatory mechanism underlying gene expression.
We further present evidence for the clinical importance of the posttranscriptional regulation of mRNA stability and its implications for drug discovery.
American Psychological Association (APA)
Sugiura, Reiko& Satoh, Ryosuke& Ishiwata, Shunji& Umeda, Nanae& Kita, Ayako. 2011. Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-447187
Modern Language Association (MLA)
Sugiura, Reiko…[et al.]. Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway. Journal of Signal Transduction No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-447187
American Medical Association (AMA)
Sugiura, Reiko& Satoh, Ryosuke& Ishiwata, Shunji& Umeda, Nanae& Kita, Ayako. Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-447187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447187