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Paeoniae alba Radix Promotes Peripheral Nerve Regeneration
Joint Authors
Yao, Chun-Hsu
Lee, Han-Chung
Huang, Chih-Yang
Tsai, Fuu-Jen
Bau, Da-Tian
Chen, Yueh-Sheng
Huang, Kun-Shan
Lin, Jaung-Geng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study provides in vitro and in vivo evaluation of Paeoniae alba Radix (PR) on peripheral nerve regeneration.
In the in vitro study, we found the PR caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as their expression of growth associated protein 43 and synapsin I.
In the in vivo study, silicone rubber chambers filled with the PR water extract were used to bridge a 10-mm sciatic nerve defect in rats.
At the conclusion of 8 weeks, regenerated nerves in the PR groups, especially at 1.25 mg ml−1 had a higher rate of successful regeneration across the wide gap, relatively larger mean values of total nerve area, myelinated axon count and blood vessel number, and a significantly larger nerve conductive velocity compared to the control group (P < .05).
These results suggest that the PR extract can be a potential nerve growth-promoting factor, being salutary in aiding the growth of injured peripheral nerve.
American Psychological Association (APA)
Huang, Kun-Shan& Lin, Jaung-Geng& Lee, Han-Chung& Tsai, Fuu-Jen& Bau, Da-Tian& Huang, Chih-Yang…[et al.]. 2011. Paeoniae alba Radix Promotes Peripheral Nerve Regeneration. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-447196
Modern Language Association (MLA)
Huang, Kun-Shan…[et al.]. Paeoniae alba Radix Promotes Peripheral Nerve Regeneration. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-447196
American Medical Association (AMA)
Huang, Kun-Shan& Lin, Jaung-Geng& Lee, Han-Chung& Tsai, Fuu-Jen& Bau, Da-Tian& Huang, Chih-Yang…[et al.]. Paeoniae alba Radix Promotes Peripheral Nerve Regeneration. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-447196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447196