Effect of Intensive Blood Pressure Control on Cardiovascular Remodeling in Hypertensive Patients with Nephrosclerosis
Joint Authors
Pogue, Velvie
Randall, Otelio
Xu, Shichen
Greene, Tom
Ketete, Muluemebet
Retta, Tamrat
Agodoa, Lawrence
Norris, Keith
Wang, Xuelei
Kwagyan, John
Jamerson, Kenneth
Source
International Journal of Nephrology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pulse pressure (PP), a marker of arterial system properties, has been linked to cardiovascular (CV) complications.
We examined (a) association between unit changes of PP and (i) composite CV outcomes and (ii) development of left-ventricular hypertrophy (LVH) and (b) effect of mean arterial pressure (MAP) control on rate of change in PP.
We studied 1094 nondiabetics with nephrosclerosis in the African American Study of Kidney Disease and Hypertension.
Subjects were randomly assigned to usual MAP goal (102–107 mmHg) or a lower MAP goal (≤92 mmHg) and randomized to beta-blocker, angiotensin converting enzyme inhibitor, or calcium channel blocker.
After covariate adjustment, a higher PP was associated with increased risk of CV outcome (RR = 1.28, CI = 1.11–1.47, P<0.01) and new LVH (RR = 1.26, CI = 1.04–1.54, P=0.02).
PP increased at a greater rate in the usual than in lower MAP groups (slope ± SE: 1.08 ± 0.15 versus 0.42 ± 0.15 mmHg/year, P=0.002), but not by the antihypertensive treatment assignment.
Observations indicate that control to a lower MAP slows the progression of PP, a correlate of cardiovascular remodeling and complications, and may be beneficial to CV health.
American Psychological Association (APA)
Randall, Otelio& Kwagyan, John& Retta, Tamrat& Jamerson, Kenneth& Pogue, Velvie& Norris, Keith…[et al.]. 2013. Effect of Intensive Blood Pressure Control on Cardiovascular Remodeling in Hypertensive Patients with Nephrosclerosis. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-447211
Modern Language Association (MLA)
Randall, Otelio…[et al.]. Effect of Intensive Blood Pressure Control on Cardiovascular Remodeling in Hypertensive Patients with Nephrosclerosis. International Journal of Nephrology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-447211
American Medical Association (AMA)
Randall, Otelio& Kwagyan, John& Retta, Tamrat& Jamerson, Kenneth& Pogue, Velvie& Norris, Keith…[et al.]. Effect of Intensive Blood Pressure Control on Cardiovascular Remodeling in Hypertensive Patients with Nephrosclerosis. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-447211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447211