Inhibition of the Growth of Plasmodium falciparum in Culture by Stearylamine-Phosphatidylcholine Liposomes
Joint Authors
Garg, Neha
Hasan, Gulam Mustafa
Surolia, Ranu
Ghosh, Prahlad Chandra
Dogra, Enna
Source
Journal of Parasitology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We have examined the effect of stearylamine (SA) in liposomes on the viability of Plasmodium falciparum in culture by studying the inhibition of incorporation of [3H]-hypoxanthine in the nucleic acid of parasites.
Stearylamine in liposomes significantly inhibits the growth of the parasites depending on the phospholipids composition.
The maximum inhibition was observed when SA was delivered through Soya phosphatidylcholine (SPC) liposomes.
The chain length of alkyl group and density of SA in liposomes play a significant role in inhibiting the growth of the parasites.
Incorporation of either cholesterol or Distearylphosphatidylethanolamine−Methoxy-Polyethylene glycol-2000 (DSPE-mPEG-2000) in Soya phosphatidylcholine-stearylamine (SPC-SA) liposomes improves the efficacy.
Intraerythrocytic entry of intact SPC-SA liposomes into infected erythrocytes was visualized using fluorescent microscopy.
No hemolysis was observed in uninfected erythrocytes, and slight hemolysis was noted in infected erythrocytes at high concentrations of SPC-SA liposomes.
Overall, our data suggested SA in SPC-liposomes might have potential application in malaria chemotherapy.
American Psychological Association (APA)
Hasan, Gulam Mustafa& Garg, Neha& Dogra, Enna& Surolia, Ranu& Ghosh, Prahlad Chandra. 2011. Inhibition of the Growth of Plasmodium falciparum in Culture by Stearylamine-Phosphatidylcholine Liposomes. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-447248
Modern Language Association (MLA)
Hasan, Gulam Mustafa…[et al.]. Inhibition of the Growth of Plasmodium falciparum in Culture by Stearylamine-Phosphatidylcholine Liposomes. Journal of Parasitology Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-447248
American Medical Association (AMA)
Hasan, Gulam Mustafa& Garg, Neha& Dogra, Enna& Surolia, Ranu& Ghosh, Prahlad Chandra. Inhibition of the Growth of Plasmodium falciparum in Culture by Stearylamine-Phosphatidylcholine Liposomes. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-447248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447248