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A Comparative Study on the Interaction of Sulfonamide and Nanosulfonamide with Human Serum Albumin
Joint Authors
Behbehani, Gholamreza Rezaei
Barzegar, Lyla
Hossaini Sadr, Moayed
Nabipur, H.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Binding parameters of the N-phenyl benzene sulfonyl hydrazide, sulfonamide, and nanosulfonamide interaction with human serum albumin were determined by calorimetry method.
The obtained binding parameters indicated that sulfonamide in the second binding sites has higher affinity for binding than the first binding sites.
The binding process of sulfonamide to HSA is both enthalpy and entropy driven.
The associated equilibrium constants confirm that sulfonamide binds to HSA with high affinity (2.2×106 and 3.86105 M−1 for first and second sets of binding sites, resp.).
The obtained results indicate that sulfonamide increases the HSA antioxidant property.
Nanosulfonamide has much more affinity for HSA (3.6×106 M−1) than sulfonamide.
American Psychological Association (APA)
Behbehani, Gholamreza Rezaei& Hossaini Sadr, Moayed& Nabipur, H.& Barzegar, Lyla. 2013. A Comparative Study on the Interaction of Sulfonamide and Nanosulfonamide with Human Serum Albumin. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-447251
Modern Language Association (MLA)
Behbehani, Gholamreza Rezaei…[et al.]. A Comparative Study on the Interaction of Sulfonamide and Nanosulfonamide with Human Serum Albumin. Journal of Chemistry No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-447251
American Medical Association (AMA)
Behbehani, Gholamreza Rezaei& Hossaini Sadr, Moayed& Nabipur, H.& Barzegar, Lyla. A Comparative Study on the Interaction of Sulfonamide and Nanosulfonamide with Human Serum Albumin. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-447251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447251