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The Role(s) of CytokinesChemokines in Urinary Bladder Inflammation and Dysfunction
Joint Authors
Vizzard, Margaret A.
Gonzalez, Eric J.
Arms, Lauren
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-11
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a chronic pain syndrome characterized by pain, pressure, or discomfort perceived to be bladder related and with at least one urinary symptom.
It was recently concluded that 3.3–7.9 million women (>18 years old) in the United States exhibit BPS/IC symptoms.
The impact of BPS/IC on quality of life is enormous and the economic burden is significant.
Although the etiology and pathogenesis of BPS/IC are unknown, numerous theories including infection, inflammation, autoimmune disorder, toxic urinary agents, urothelial dysfunction, and neurogenic causes have been proposed.
Altered visceral sensations from the urinary bladder (i.e., pain at low or moderate bladder filling) that accompany BPS/IC may be mediated by many factors including changes in the properties of peripheral bladder afferent pathways such that bladder afferent neurons respond in an exaggerated manner to normally innocuous stimuli (allodynia).
The goals for this review are to describe chemokine/receptor (CXCL12/CXCR4; CCL2/CCR2) signaling and cytokine/receptor (transforming growth factor (TGF-β)/TGF-β type 1 receptor) signaling that may be valuable LUT targets for pharmacologic therapy to improve urinary bladder function and reduce somatic sensitivity associated with urinary bladder inflammation.
American Psychological Association (APA)
Gonzalez, Eric J.& Arms, Lauren& Vizzard, Margaret A.. 2014. The Role(s) of CytokinesChemokines in Urinary Bladder Inflammation and Dysfunction. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-447255
Modern Language Association (MLA)
Gonzalez, Eric J.…[et al.]. The Role(s) of CytokinesChemokines in Urinary Bladder Inflammation and Dysfunction. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-447255
American Medical Association (AMA)
Gonzalez, Eric J.& Arms, Lauren& Vizzard, Margaret A.. The Role(s) of CytokinesChemokines in Urinary Bladder Inflammation and Dysfunction. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-447255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447255