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Elevated Serum C-Reactive Protein Relates to Increased Cerebral Myoinositol Levels in Middle-Aged Adults
Joint Authors
Haley, Andreana P.
Stautberg, Sandra
Eagan, Danielle E.
Tarumi, Takashi
Tanaka, Hirofumi
Gonzales, Mitzi M.
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
C-reactive protein (CRP), a systemic marker of inflammation, is a risk factor for late life cognitive impairment and dementia, yet the mechanisms that link elevated CRP to cognitive decline are not fully understood.
In this study we examined the relationship between CRP and markers of neuronal integrity and cerebral metabolism in middle-aged adults with intact cognitive function, using proton magnetic resonance spectrocospy.
We hypothesized that increased levels of circulating CRP would correlate with changes in brain metabolites indicative of early brain vulnerability.
Thirty-six individuals, aged 40 to 60, underwent neuropsychological assessment, a blood draw for CRP quantification, and 1H MRS examining N-acetyl-aspartate, myo-inositol, creatine, choline, and glutamate concentrations in occipito-parietal grey matter.
Independent of age, sex and education, serum CRP was significantly related to higher cerebral myo-inositol/creatine ratio (F(4,31)=4.74, P=0.004), a relationship which remained unchanged after adjustment for cardiovascular risk (F(5,30)=4.356, CRP β = 0.322, P=0.045).
Because these biomarkers are detectable in midlife they may serve as useful indicators of brain vulnerability during the preclinical period when mitigating intervention is still possible.
American Psychological Association (APA)
Eagan, Danielle E.& Gonzales, Mitzi M.& Tarumi, Takashi& Tanaka, Hirofumi& Stautberg, Sandra& Haley, Andreana P.. 2012. Elevated Serum C-Reactive Protein Relates to Increased Cerebral Myoinositol Levels in Middle-Aged Adults. Cardiovascular Psychiatry and Neurology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-447258
Modern Language Association (MLA)
Eagan, Danielle E.…[et al.]. Elevated Serum C-Reactive Protein Relates to Increased Cerebral Myoinositol Levels in Middle-Aged Adults. Cardiovascular Psychiatry and Neurology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-447258
American Medical Association (AMA)
Eagan, Danielle E.& Gonzales, Mitzi M.& Tarumi, Takashi& Tanaka, Hirofumi& Stautberg, Sandra& Haley, Andreana P.. Elevated Serum C-Reactive Protein Relates to Increased Cerebral Myoinositol Levels in Middle-Aged Adults. Cardiovascular Psychiatry and Neurology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-447258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447258