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Early Degenerative Effects of Diabetes Mellitus on Pancreas, Liver, and Kidney in Rats : An Immunohistochemical Study
Joint Authors
Ozmen, Ozlem
Topsakal, Senay
Haligur, Mehmet
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Liver and kidney commonly affected by diabetes in chronic cases but pathogenetic mechanisms are not fully understood in early stages of the disease.
The aim of this study was to investigate the immunohistochemical expression of caspase-3, cyclooxygenase (COX)-1 and-2, calcium sensing receptor (CSR), and hypoxia inducible factor-1α (HIF-1α) in pancreas, liver, and kidney in streptozotocin (STZ) induced DM.
Study group (n = 6) were received streptozotocin (50 mg/kg) and control group (n = 6) physiologic saline.
The blood glucose and ketonuria were measured, and necropsy was performed on them on third, fourth, and fifth days.
Immunohistochemistry revealed that marked increase in caspase-3 reaction pancreas, liver, and kidney in the study group than control group.
COX-1 slightly increased in these organs in study group compared to controls.
Immunohistochemically COX-2 reaction was markedly positive in liver and kidney, but slightly increased in pancreas.
The most increased reaction was observed in CRS and all organs were markedly positive.
HIF-1α expression was also increased but the reaction was more severe in pancreas than liver and kidney.
This study indicated that degeneration starts in organs in early stages of the disease and the most effective route for degeneration related to increase of calcium influx and hypoxia upon cells in DM.
American Psychological Association (APA)
Haligur, Mehmet& Topsakal, Senay& Ozmen, Ozlem. 2012. Early Degenerative Effects of Diabetes Mellitus on Pancreas, Liver, and Kidney in Rats : An Immunohistochemical Study. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-447264
Modern Language Association (MLA)
Haligur, Mehmet…[et al.]. Early Degenerative Effects of Diabetes Mellitus on Pancreas, Liver, and Kidney in Rats : An Immunohistochemical Study. Experimental Diabetes Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-447264
American Medical Association (AMA)
Haligur, Mehmet& Topsakal, Senay& Ozmen, Ozlem. Early Degenerative Effects of Diabetes Mellitus on Pancreas, Liver, and Kidney in Rats : An Immunohistochemical Study. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-447264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447264