Role of Tumor Associated Fibroblasts in Human Liver Regeneration, Cirrhosis, and Cancer
Joint Authors
Comisso, Elisa
Toffoletto, Barbara
Marzinotto, Stefania
Pucer, Anja
Cesselli, Daniela
Puppato, Elisa
Beltrami, Carlo Alberto
Poz, Alessandra
Baccarani, Umberto
Bergamin, Natascha
Avellini, Claudio
Sorrentino, Marisa
Bourkoula, Evgenia
Beltrami, Antonio Paolo
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Tumor associated fibroblasts (TAFs) are considered a microenvironmental element critical for tumor growth and progression.
Experimental studies suggest that their origin could be from mesenchymal stem cells (MSCs) derived from the bone marrow.
However, the role played by TAFs in cirrhosis, hepatocellular carcinoma development, and progression is largely unknown, and in vitro human models are missing.
This paper for the first time demonstrates that (1) human neoplastic livers possess a population of multipotent adult stem cells (MASCs) with properties of TAFs; (2) a population of MASC-derived TAFs is already present in cirrhotic, not yet neoplastic, livers; (3) MASCs isolated from nonneoplastic and noncirrhotic liver scan acquire a TAF phenotype when grown in a medium conditioned by tumor cell lines, supporting the notion that TAF could originate from resident primitive cells (MASCs), possibly through a paracrine mechanism.
American Psychological Association (APA)
Cesselli, Daniela& Beltrami, Antonio Paolo& Poz, Alessandra& Marzinotto, Stefania& Comisso, Elisa& Bergamin, Natascha…[et al.]. 2011. Role of Tumor Associated Fibroblasts in Human Liver Regeneration, Cirrhosis, and Cancer. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-447285
Modern Language Association (MLA)
Cesselli, Daniela…[et al.]. Role of Tumor Associated Fibroblasts in Human Liver Regeneration, Cirrhosis, and Cancer. International Journal of Hepatology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-447285
American Medical Association (AMA)
Cesselli, Daniela& Beltrami, Antonio Paolo& Poz, Alessandra& Marzinotto, Stefania& Comisso, Elisa& Bergamin, Natascha…[et al.]. Role of Tumor Associated Fibroblasts in Human Liver Regeneration, Cirrhosis, and Cancer. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-447285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447285