Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity
Joint Authors
Prasanna Kumar, Basavapatna N.
Mallesha, Lingappa
Mohana, Kikkeri Narasimha Shetty
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A series of some new 2,5-disubstituted-1,3,4-oxadiazoles 4(a–i) have been conveniently synthesized by intramolecular oxidative cyclization of (E)-2-(arylbenzylidene)-2-[(4-methoxyphenyl)amino]acetohydrazides promoted by iodobenzene diacetate as an oxidant.
The structures of the synthesized compounds have been confirmed by 1H and 13C NMR, IR, MS, and elemental analysis.
All the newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock (MES) seizure method.
Compounds 4g, 4d, and 4a were found to be the most potent of this series.
The same compounds showed no neurotoxicity at the maximum dose administered.
American Psychological Association (APA)
Prasanna Kumar, Basavapatna N.& Mohana, Kikkeri Narasimha Shetty& Mallesha, Lingappa. 2013. Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447293
Modern Language Association (MLA)
Prasanna Kumar, Basavapatna N.…[et al.]. Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-447293
American Medical Association (AMA)
Prasanna Kumar, Basavapatna N.& Mohana, Kikkeri Narasimha Shetty& Mallesha, Lingappa. Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447293