Recombinant nAG (a Salamander-Derived Protein) Decreases the Formation of Hypertrophic Scarring in the Rabbit Ear Model
Joint Authors
al-Qattan, Mohammad M.
Shier, Medhat K.
Abd-Al Wahed, Mervat M.
Alhumidi, Ahmed A.
Hawary, Khalid
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
nAG (newt-Anterrior Gradient) protein is the key mediator of regrowth of amputated limbs in salamanders.
In a previous work in our lab, a new nAG gene (suitable for humans) was designed and cloned.
The cloned vector was transfected into primary human fibroblasts.
The expression of nAG in human primary fibroblasts was found to suppress collagen expression.
The current study shows that local injection of recombinant nAG reduces scar hypertrophy in the rabbit ear model.
This is associated with lower scar elevation index (SEI), lower levels of collagen I & III, higher levels of MMP1, and a higher degree of scar maturation in experimental wounds compared to controls.
American Psychological Association (APA)
al-Qattan, Mohammad M.& Abd-Al Wahed, Mervat M.& Hawary, Khalid& Alhumidi, Ahmed A.& Shier, Medhat K.. 2014. Recombinant nAG (a Salamander-Derived Protein) Decreases the Formation of Hypertrophic Scarring in the Rabbit Ear Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-447299
Modern Language Association (MLA)
al-Qattan, Mohammad M.…[et al.]. Recombinant nAG (a Salamander-Derived Protein) Decreases the Formation of Hypertrophic Scarring in the Rabbit Ear Model. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-447299
American Medical Association (AMA)
al-Qattan, Mohammad M.& Abd-Al Wahed, Mervat M.& Hawary, Khalid& Alhumidi, Ahmed A.& Shier, Medhat K.. Recombinant nAG (a Salamander-Derived Protein) Decreases the Formation of Hypertrophic Scarring in the Rabbit Ear Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-447299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447299