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Cation Involvement in Telomestatin Binding to G-Quadruplex DNA
Joint Authors
Rosu, Frédéric
Mazzucchelli, Gabriel
Shin-ya, Kazuo
De Pauw, Edwin
Smargiasso, Nicolas
Gabelica, Valérie
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The binding mode of telomestatin to G-quadruplex DNA has been investigated using electrospray mass spectrometry, by detecting the intact complexes formed in ammonium acetate.
The mass measurements show the incorporation of one extra ammonium ion in the telomestatin complexes.
Experiments on telomestatin alone also show that the telomestatin alone is able to coordinate cations in a similar way as a crown ether.
Finally, density functional theory calculations suggest that in the G-quadruplex-telomestatin complex, potassium or ammonium cations are located between the telomestatin and a G-quartet.
This study underlines that monovalent cation coordination capabilities should be integrated in the rational design of G-quadruplex binding ligands.
American Psychological Association (APA)
Rosu, Frédéric& Gabelica, Valérie& Smargiasso, Nicolas& Mazzucchelli, Gabriel& Shin-ya, Kazuo& De Pauw, Edwin. 2010. Cation Involvement in Telomestatin Binding to G-Quadruplex DNA. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-447307
Modern Language Association (MLA)
Rosu, Frédéric…[et al.]. Cation Involvement in Telomestatin Binding to G-Quadruplex DNA. Journal of Nucleic Acids No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-447307
American Medical Association (AMA)
Rosu, Frédéric& Gabelica, Valérie& Smargiasso, Nicolas& Mazzucchelli, Gabriel& Shin-ya, Kazuo& De Pauw, Edwin. Cation Involvement in Telomestatin Binding to G-Quadruplex DNA. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-447307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447307