Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7)‎ in Smooth Muscles

Abstract EN

Ang-(1–7) is produced via degradation of Ang II by the human angiotensin converting enzyme, also known as ACE2.

In the cardiovascular system, Ang-(1–7) has been shown to produce effects that are opposite to those of Ang II.

These include smooth muscle relaxation and cardioprotection.

While the roles of Ang-(1–7) in other systems are currently topic of intense research, functional data suggest a relaxation action in gastrointestinal smooth muscles in a way that corroborates the results obtained from vascular tissues.

However, more studies are necessary to determine a relevant role for Ang-(1–7) in the gastrointestinal system.

The Ang-(1–7) actions are mediated by a distinct, functional, Ang-(1–7) receptor: the Mas receptor as shown by diverse studies involving site-specific binding techniques, selective antagonists, and targeted gene deletion.

This paper provides an overview of the functional role and the molecular pathways involved in the biosynthesis and activity of Ang-(1–7) in diverse systems.