Chelation Therapy with Oral Solution of Deferiprone in Transfusional Iron-Overloaded Children with Hemoglobinopathies

Joint Authors

Karagouni, Paraskevi
Makis, Alexandros
Chaliasos, Nikolaos
Alfantaki, Sapfo
Siamopoulou, Antigone

Source

Anemia

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-11-04

Country of Publication

Egypt

No. of Pages

3

Main Subjects

Diseases

Abstract EN

Iron overload in hemoglobinopathies is secondary to blood transfusions, chronic hemolysis, and increased iron absorption and leads to tissue injury requiring the early use of chelating agents.

The available agents are parenteral deferoxamine and oral deferiprone and deferasirox.

There are limited data on the safety and efficacy of deferiprone at a very young age.

The aim of our study was the presentation of data regarding the use of oral solution of deferiprone in 9 children (mean age 6.5, range 2–10) with transfusion dependent hemoglobinopathies (6 beta thalassemia major, 1 thalassemia intermedia, and 2 sickle cell beta thalassemia).

The mean duration of treatment was 21.5 months (range 15–31).

All children received the oral solution without any problems of compliance.

Adverse reactions were temporary abdominal discomfort and diarrhea (1 child), mild neutropenia (1 child) that resolved with no need of discontinuation of treatment, and transient arthralgia (1 child) that resolved spontaneously.

The mean ferritin levels were significantly reduced at the end of 12 months (initial 2440 versus final 1420 μg/L, P<0.001).

This small study shows that oral solution of deferiprone was well tolerated by young children and its use was not associated with major safety concerns.

Furthermore, it was effective in decreasing serum ferritin.

American Psychological Association (APA)

Makis, Alexandros& Chaliasos, Nikolaos& Alfantaki, Sapfo& Karagouni, Paraskevi& Siamopoulou, Antigone. 2013. Chelation Therapy with Oral Solution of Deferiprone in Transfusional Iron-Overloaded Children with Hemoglobinopathies. Anemia،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-447350

Modern Language Association (MLA)

Makis, Alexandros…[et al.]. Chelation Therapy with Oral Solution of Deferiprone in Transfusional Iron-Overloaded Children with Hemoglobinopathies. Anemia No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-447350

American Medical Association (AMA)

Makis, Alexandros& Chaliasos, Nikolaos& Alfantaki, Sapfo& Karagouni, Paraskevi& Siamopoulou, Antigone. Chelation Therapy with Oral Solution of Deferiprone in Transfusional Iron-Overloaded Children with Hemoglobinopathies. Anemia. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-447350

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-447350