The In Vitro Antibiotic Susceptibility of Malaysian Isolates of Burkholderia pseudomallei
Joint Authors
Mohd Noor, Azura
Ahmad, Norazah
Hashim, Rohaidah
Source
International Journal of Microbiology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Acute melioidosis may present as localised or septicaemic infections and can be fatal if left untreated.
Burkholderia pseudomallei resistant to antibiotics used for the treatment of melioidosis had been reported.
The aim of this study was to determine the in vitro antibiotic susceptibility patterns of Burkholderia pseudomallei isolated in Malaysia to a panel of antibiotics used for the treatment of melioidosis and also to potential alternative antibiotics such as tigecycline, ampicillin/sulbactam, and piperacillin/tazobactam.
A total of 170 Burkholderia pseudomallei isolates were subjected to minimum inhibitory concentration determination using E-test method to eleven antibiotics.
All isolates were sensitive to meropenem and piperacillin/tazobactam.
For ceftazidime, imipenem, amoxicillin/clavulanic acid, and doxycycline resistance was observed in 1 isolate (0.6%) for each of the antibiotics.
Trimethoprim/sulfamethoxazole resistance was observed in 17 (10%) isolates.
For other antibiotics, ampicillin/sulbactam, chloramphenicol, tigecycline, and ciprofloxacin resistance were observed in 1 (0.6%), 6 (3.5%), 60 (35.3%) and 98 (57.7%) isolates respectively.
One isolate B170/06 exhibited resistance to 4 antibiotics, namely, ciprofloxacin, chloramphenicol, trimethoprim/sulfamethoxazole, and tigecycline.
In conclusion, the Malaysian isolates were highly susceptible to the current antibiotics used in the treatment of melioidosis in Malaysia.
Multiple resistances to the antibiotics used in the maintenance therapy are the cause for a concern.
American Psychological Association (APA)
Ahmad, Norazah& Hashim, Rohaidah& Mohd Noor, Azura. 2013. The In Vitro Antibiotic Susceptibility of Malaysian Isolates of Burkholderia pseudomallei. International Journal of Microbiology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447360
Modern Language Association (MLA)
Ahmad, Norazah…[et al.]. The In Vitro Antibiotic Susceptibility of Malaysian Isolates of Burkholderia pseudomallei. International Journal of Microbiology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-447360
American Medical Association (AMA)
Ahmad, Norazah& Hashim, Rohaidah& Mohd Noor, Azura. The In Vitro Antibiotic Susceptibility of Malaysian Isolates of Burkholderia pseudomallei. International Journal of Microbiology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447360