NTPDase5PCPH as a New Target in Highly Aggressive Tumors : A Systematic Review
Joint Authors
Wink, Márcia Rosângela
Bracco, Paula Andreghetto
Bertoni, Ana Paula Santin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The protooncogene PCPH was recently identified as being the ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5).
This protooncogene is converted into an oncogene by a single base pair deletion, resulting in frame change and producing a premature stop codon, leading to a mutated protein (mt-PCPH) with only 27 kDa, which is much smaller than the original 47 kDa protein.
Overexpression of the PCPH as well as the mutated PCPH increases the cellular resistance to stress and apoptosis.
This is intriguing considering that the active form, that is, the oncogene, is the mutated PCPH.
Several studies analyzed the expression of NTPDase5/mt-PCPH in a wide range of tumor cells and evaluated its role and mechanisms in cancer and other pathogenic processes.
The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets.
American Psychological Association (APA)
Bracco, Paula Andreghetto& Bertoni, Ana Paula Santin& Wink, Márcia Rosângela. 2014. NTPDase5PCPH as a New Target in Highly Aggressive Tumors : A Systematic Review. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-447375
Modern Language Association (MLA)
Bracco, Paula Andreghetto…[et al.]. NTPDase5PCPH as a New Target in Highly Aggressive Tumors : A Systematic Review. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-447375
American Medical Association (AMA)
Bracco, Paula Andreghetto& Bertoni, Ana Paula Santin& Wink, Márcia Rosângela. NTPDase5PCPH as a New Target in Highly Aggressive Tumors : A Systematic Review. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-447375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447375